Research & Teaching

Research

BSc:

He undertook an 8 month period of laboratory based research based on human endothelial cell culture in the department of Immunology, Rayne Institute, St Thomas Hospital in 1989. Collaboration with the department of Haematology led to the thesis "The Adherence of Erythrocytes to Cytokine-Treated Endothelium" and subsequent publications. This work resulted in MRC funded collaboration with the sickle cell referencing centre. He also undertook practical and literary research into external eye disease and laser applications in the eye.

PhD:

I was awarded a PhD for a British Heart Foundation funded research fellowship at the Unit of Critical Care, National Heart and Lung institute, and the Physiological Flow Studies Group, Imperial College School of Medicine, London. The research investigated structural and functional changes in the microcirculation in sepsis; the work involved utilisation of intravital microscopy to assess the microcirculatory changes (particularly permeability) in an in vivo model of severe sepsis. He established the intravital microscopy set-up, within the research group. This was part of Professor TW Evan’s research group involved in vascular biology in the critically ill.

Clinical:

ARDS:

He was one of 3 bronchoscopists involved in a clinical pilot study looking at the effects of a neutrophil elastase inhibitor ZD8321 (Zeneca pharma) on Neutrophil migration to the lungs of patients following cardiopulmonary bypass surgery.

Diagnostic bronchoscopy –TBNA and Rinse biopsies:

He is involved in several clinical research projects involving diagnostic bronchoscopic techniques (Transbronchial needle aspiration, endobronchial ultrasound and diathermy forceps biopsies) in lung malignancy, Bronchial Thermoplasty for Asthma and new bronchoscopic sampling techniques and valves for emphysema.

Interstitial Lung Disease:

Study of the clinico-patho-radiologic features of chronic EAA in a retrospective study at the Royal Brompton Hospital with Professors Athol Wells, David Hansell and Andrew Nicholson.

ICU:

Westminster Medical School Grant – A comparison of Bronchoscopic microsample probes and Bronchoalveolar Lavage for analysis of inflammatory markers in Burns related inhalational injury and acute lung injury. Evaluation of Critical Care Outreach service impact – qualitative and quantitative.

Teaching

Director of Clinical Studies (Undergraduate medicine) – Chelsea and Westminster Campus, Imperial College, London Educational Subcommittee member – North Thames STC in Respiratory Medicine IBTICM Local Tutor for Intensive Care Medicine